Maternal exercise and growth restriction in rats alters placental angiogenic factors and blood space area in a sex-specific manner

YT Mangwiro; JF Briffa; S Gravina; D Mahizir; K Anevska; T Romano; KM Moritz; JS Cuffe; ME Wlodek

Journal article

Maternal exercise and growth restriction in rats alters placental angiogenic factors and blood space area in a sex-specific manner

YT Mangwiro, JF Briffa, S Gravina, D Mahizir, K Anevska, T Romano, KM Moritz, JS Cuffe, ME Wlodek

Placenta | W B SAUNDERS CO LTD | Published : 2018

DOI: 10.1016/j.placenta.2018.12.005

Abstract

Fetal growth and development are dependent on adequate placental nutrient transfer. The surface area of the placental villous network is a key determinant of nutrient exchange, which is regulated by vasculogenic and angiogenic factors. These factors are altered by intrauterine growth restriction (IUGR) and maternal obesity in both the first (F1) and second (F2) generations. We investigated the impact of endurance exercise in IUGR dams fed a High-fat diet on placental vasculogenesis and angiogenesis. Uteroplacental insufficiency (Restricted) or sham (Control) surgery was induced on embryonic day (E) 18 in Wistar-Kyoto rats. F1 offspring were fed a Chow or High-fat diet from weaning, and at 16..

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University of Melbourne Researchers

Yeukai Mangwiro Author

Jessica Briffa Author

Mary Wlodek Author

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Grants

Awarded by Diabetes Australia Research Trust

Funding Acknowledgements

This research was supported by the National Health and Medical Research Council (NHMRC) of Australia (M.E.W.; 1045602) and a 2013 Diabetes Australia Research Trust Research Project (M.E.W). J.F.B. holds a Faculty of Medicine, Dentistry and Health Science Postdoctoral Fellowship at the University of Melbourne. Y.T.M.M. and K.A. hold a La Trobe University Post Graduate Award and D.M. held a Malaysia Government Scholarship.